Sex differences associated with corpus callosum development in human infants: A longitudinal multimodal imaging study.

ABSTRACT: The corpus callosum (CC) is the largest connective pathway in the human brain, linking cerebral hemispheres. There is longstanding debate in the scientific literature whether sex differences are evident in this structure, with many studies indicating the structure is larger in females. However, there are few data pertaining to this issue in infancy, during which time the most rapid developmental changes to the CC occur. In this study, we examined longitudinal brain imaging data collected from 104 infants at ages 6, 12, and 24 months. We identified sex differences in brain-size adjusted CC area and thickness characterized by a steeper rate of growth in males versus females from ages 6-24 months. In contrast to studies of older children and adults, CC size was larger for male compared to fem

SUBMITTER: Schmied A 

PROVIDER: S-EPMC7292750 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature