Predictors of survival in patients undergoing oropharyngeal surgery for cancer recurrence after radiation therapy.

ABSTRACT:

Purpose

The incidence of oropharyngeal squamous cell carcinoma continues to rise with the majority of patients receiving definitive or adjunctive radiation. For patients with locoregional recurrence after radiation, optimal treatment involves salvage surgery. The aim of this study is to identify factors that predict survival to ultimately improve patient selection for salvage surgery.

Methods

Retrospective cohort study at an NCI-designated cancer center. We analyzed patients with a history of head and neck radiation who presented with persistent/recurrent or second primary disease requiring salvage oropharyngeal resection from 1998-2017 (n = 120). Patients were stratified into three classes based on time to recurrence and presence of laryngopharyngeal dysfunction. Primary ou

SUBMITTER: Heft Neal ME 

PROVIDER: S-EPMC7292755 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature