Small airways pathology in idiopathic pulmonary fibrosis: a retrospective cohort study.

ABSTRACT:

Background

The observation that patients with idiopathic pulmonary fibrosis (IPF) can have higher than normal expiratory flow rates at low lung volumes led to the conclusion that the airways are spared in IPF. This study aimed to re-examine the hypothesis that airways are spared in IPF using a multiresolution imaging protocol that combines multidetector CT (MDCT), with micro-CT and histology.

Methods

This was a retrospective cohort study comparing explanted lungs from patients with severe IPF treated by lung transplantation with a cohort of unused donor (control) lungs. The donor control lungs had no known lung disease, comorbidities, or structural lung injury, and were deemed appropriate for transplantation on review of the clinical files. The diagnosis of IPF in the lungs

SUBMITTER: Verleden SE 

PROVIDER: S-EPMC7292784 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature