Effect of size and location of simulated lytic lesions on the structural properties of human vertebral bodies, a micro-finite element study.

ABSTRACT: Currently, the Spinal Instability Neoplastic Score system is used in clinics to evaluate the risk of fracture in patients with spinal metastases. This method, however, does not always provide a clear guideline due to the complexity in accounting for the effect of metastatic lesions on vertebral stability. The aim of this study was to use a validated micro Finite Element (microFE) modelling approach to analyse the effect of the size and location of lytic metastases on the mechanical properties of human vertebral bodies. Micro Computed Tomography based microFE models were generated with and without lytic lesions simulated as holes within a human vertebral body. Single and multiple lytic lesions were simulated with four different sizes and in five different locations. Bone was assumed homogen

SUBMITTER: Costa MC 

PROVIDER: S-EPMC7292861 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature