Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice.

ABSTRACT:

Objective

Hypothalamic arcuate proopiomelanocortin (Arc-POMC) neurons are involved in different physiological processes such as the regulation of energy balance, glucose homeostasis, and stress-induced analgesia. Since these neurons heterogeneously express different biological markers and project to many hypothalamic and extrahypothalamic areas, it is proposed that Arc-POMC neurons could be classified into different subpopulations having diverse physiological roles. The aim of the present study was to characterize the contribution of the subpopulation of Arc-POMC neurons cosecreting gamma-aminobutyric acid (GABA) neurotransmitter in the control of energy balance.

Methods

Arc-Pomc expression restricted to GABAergic-POMC neurons was achieved by crossing a reversible Pomc-defic

SUBMITTER: Trotta M 

PROVIDER: S-EPMC7292867 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature