The effect of age on the microarchitecture and profile of gene expression in femoral head and neck bone from patients with osteoarthritis.

ABSTRACT: Ageing of the skeleton is characterised by decreased bone mineral density, reduced strength, and increased risk of fracture. Although it is known that these changes are determined by the activities of bone cells through the processes of bone modelling and remodelling, details of the molecular mechanisms that underlie age-related changes in bone are still missing. Here, we analysed age-related changes in bone microarchitecture along with global gene expression in samples obtained from patients with osteoarthritis (OA). We hypothesised that changes would be evident in both microarchitecture and gene expression and aimed to identify novel molecular mechanisms that underlie ageing processes in bone. Samples of femoral head and neck were obtained from patients undergoing hip arthroplasty for OA

SUBMITTER: Naot D 

PROVIDER: S-EPMC7292911 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature