Association of Glycated Hemoglobin Levels With Risk of Pancreatic Cancer.

ABSTRACT:

Importance

New-onset diabetes after the age of 50 years is a potential indicator of pancreatic cancer. Understanding the associations between hyperglycemia, diabetes, and pancreatic cancer, including pancreatic ductal adenocarcinoma, is key to developing an approach to early detection.

Objective

To assess the association of elevation in glycated hemoglobin (HbA1c) with the risk of pancreatic cancer.

Design, setting, and participants

This cohort study was conducted using data collected from an integrated health care system in California. A total of 851 402 patients aged 50 to 84 years who had HbA1c measurements taken between 2010 and 2014 were identified as the base cohort, with 12 contemporaneous cohorts created based on varying HbA1c thresholds (ie, 6.1%, 6.3%, 6.5%,

SUBMITTER: Wu BU 

PROVIDER: S-EPMC7292999 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature