Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson's disease rat model.

ABSTRACT: Parkinson's disease is a neurodegenerative disorder, and no treatment has been yet established to prevent disease progression. Coenzyme Q10, an antioxidant, has been considered a promising neuroprotective agent; however, conventional oral administration provides limited efficacy due to its very low bioavailability. In this study, we hypothesised that continuous, intrastriatal administration of a low dose of Coenzyme Q10 could effectively prevent dopaminergic neuron degeneration. To this end, a Parkinson's disease rat model induced by 6-hydroxydopamine was established, and the treatment was applied a week before the full establishment of this disease model. Behavioural tests showed a dramatically decreased number of asymmetric rotations in the intrastriatal Coenzyme Q10 group compared with

SUBMITTER: Park HW 

PROVIDER: S-EPMC7293316 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature