PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation.

ABSTRACT:

Background

Longevity gene klotho (KL) is associated with age-related phenotypes including lifespan, cardiometabolic disorders, cognition, and brain morphology, in part, by conferring protection against inflammation. We hypothesized that the KL/inflammation association might be altered in the presence of psychiatric stress and operate via epigenetic pathways. We examined KL polymorphisms, and their interaction with posttraumatic stress disorder (PTSD) symptoms, in association with KL DNA methylation in blood. We further examined KL DNA methylation as a predictor of longitudinal changes in a peripheral biomarker of inflammation (C-reactive protein; CRP).

Methods

The sample comprised 309 white non-Hispanic military veterans (93.5 % male; mean age: 32 years, range: 19-65; 30 % P

SUBMITTER: Wolf EJ 

PROVIDER: S-EPMC7293549 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature