Association of body mass index with longitudinal rates of retinal atrophy in multiple sclerosis.

ABSTRACT:

Background

Studies evaluating associations between body mass index (BMI) and optical coherence tomography (OCT) measures in multiple sclerosis (MS) are lacking.

Objective

To assess whether elevated BMI is associated with accelerated retinal atrophy.

Methods

In this observational study, 513 MS patients were followed with serial spectral-domain OCT for a median of 4.4 years. Participants were categorized as normal weight (BMI: 18.5-24.9 kg/m²), overweight (BMI: 25-29.9 kg/m²), and obese (BMI: ⩾30 kg/m²). Participants with diabetes mellitus or uncontrolled hypertension and eyes with optic neuritis (ON) ⩽6 months prior to baseline OCT or during follow-up were excluded. Statistical analyses were performed with mixed-effects linear regressio

SUBMITTER: Filippatou AG 

PROVIDER: S-EPMC7293552 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature