Nutrient dose-responsive transcriptome changes driven by Michaelis-Menten kinetics underlie plant growth rates.

ABSTRACT: An increase in nutrient dose leads to proportional increases in crop biomass and agricultural yield. However, the molecular underpinnings of this nutrient dose-response are largely unknown. To investigate, we assayed changes in the Arabidopsis root transcriptome to different doses of nitrogen (N)-a key plant nutrient-as a function of time. By these means, we found that rate changes of genome-wide transcript levels in response to N-dose could be explained by a simple kinetic principle: the Michaelis-Menten (MM) model. Fitting the MM model allowed us to estimate the maximum rate of transcript change (V_max), as well as the N-dose at which one-half of V_max was achieved (K_m) for 1,153 N-dose-responsive genes. Since transcription facto

SUBMITTER: Swift J 

PROVIDER: S-EPMC7293603 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature