Plasmodium vivax spleen-dependent genes encode antigens associated with cytoadhesion and clinical protection.

ABSTRACT: Plasmodium vivax, the most widely distributed human malaria parasite, causes severe clinical syndromes despite low peripheral blood parasitemia. This conundrum is further complicated as cytoadherence in the microvasculature is still a matter of investigations. Previous reports in Plasmodium knowlesi, another parasite species shown to infect humans, demonstrated that variant genes involved in cytoadherence were dependent on the spleen for their expression. Hence, using a global transcriptional analysis of parasites obtained from spleen-intact and splenectomized monkeys, we identified 67 P. vivax genes whose expression was spleen dependent. To determine their role in cytoadherence, two Plasmodium falciparum transgenic lines expressing two variant proteins pertaini

SUBMITTER: Fernandez-Becerra C 

PROVIDER: S-EPMC7293605 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature