Redox controls metabolic robustness in the gas-fermenting acetogen Clostridium autoethanogenum.

ABSTRACT: Living biological systems display a fascinating ability to self-organize their metabolism. This ability ultimately determines the metabolic robustness that is fundamental to controlling cellular behavior. However, fluctuations in metabolism can affect cellular homeostasis through transient oscillations. For example, yeast cultures exhibit rhythmic oscillatory behavior in high cell-density continuous cultures. Oscillatory behavior provides a unique opportunity for quantitating the robustness of metabolism, as cells respond to changes by inherently compromising metabolic efficiency. Here, we quantify the limits of metabolic robustness in self-oscillating autotrophic continuous cultures of the gas-fermenting acetogen Clostridium autoethanogenum Online gas analysis and high-resolution t

SUBMITTER: Mahamkali V 

PROVIDER: S-EPMC7293625 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature