Glycosaminoglycans accelerate biomimetic collagen mineralization in a tissue-based in vitro model.

ABSTRACT: Mammalian teeth are attached to the jawbone through an exquisitely controlled mineralization process: unmineralized collagen fibers of the periodontal ligament anchor directly into the outer layer of adjoining mineralized tissues (cementum and bone). The sharp interface between mineralized and nonmineralized collagenous tissues makes this an excellent model to study the mechanisms by which extracellular matrix macromolecules control collagen mineralization. While acidic phosphoproteins, localized in the mineralized tissues, play key roles in control of mineralization, the role of glycosaminoglycans (GAGs) is less clear. As several proteoglycans are found only in the periodontal ligament, it has been hypothesized that these inhibit mineralization of collagen in this tissue. Here we used an

SUBMITTER: Wojtas M 

PROVIDER: S-EPMC7293698 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature