Epstein-Barr virus co-opts TFIIH component XPB to specifically activate essential viral lytic promoters.

ABSTRACT: Epstein-Barr virus (EBV) is associated with epithelial and lymphoid malignancies, establishes latent infection in memory B cells, and intermittently produces infectious virions through lytic replication. Released virions play a key role in latent reservoir maintenance and transmission. Lytic EBV transcription differs from cellular transcription in requiring a virus-encoded preinitiation complex that binds to TATT motifs unique to EBV late lytic promoters. Expression of 15 late lytic genes that are important for virion production and infectivity is particularly dependent on the EBV SM protein, a nuclear protein expressed early during lytic reactivation that binds to viral RNAs and enhances RNA stability. We recently discovered that spironolactone blocks EBV virion production by inhibiting E

SUBMITTER: Verma D 

PROVIDER: S-EPMC7293708 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature