Polymeric Films for the Encapsulation, Storage, and Tunable Release of Therapeutic Microbes.

ABSTRACT: Microbe-based therapeutics (MBTs) are an emerging therapeutic modality for treating gastrointestinal infections and inflammatory bowel diseases. Current formulations for oral delivery of MBTs use capsules to achieve safe gastric transit, but oral formulations that control the spatiotemporal concentration of MBTs are yet to be developed, despite well-established connections between all therapeutics and their location, concentration, and distribution at sites of action. The development of a multi-functional polymer-based encapsulation system to formulate MBTs for enhanced storage and delivery through formulation of a model MBT, Lactobacillus casei ATCC393, is reported here. This approach enables the additive inclusion of excipients and polymers to grant specific functions, toward the develop

SUBMITTER: Qiu K 

PROVIDER: S-EPMC7293827 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature