Expression and clinical significance of HSP27 and its phosphorylation in lower extremity arteriosclerosis obliterans.

ABSTRACT:

Objectives

This study set out to analyze the difference of heat shock protein 27 (HSP27) and its phosphorylation in patients with lower extremity arteriosclerosis obliterans (LEASO) at different stages. This research also examined their clinical significance in this disease.

Methods

Blood samples from 60 patients with LEASO were collected and divided into two groups according to ankle-brachial index (ABI): group A (ABI ≤ 0.43) and group B (ABI > 0.43). The expression of HSP27 in each stage of Fontaine was measured by ELISA, and the difference of HSP27 concentration and ABI between the two groups was analyzed. Meanwhile, three normal femoral artery specimens (normal group) and three atherosclerotic femoral artery specimens (lesion group) were collected, and HSP27 and its Phos

SUBMITTER: Bai J 

PROVIDER: S-EPMC7293856 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature