Focused Ultrasound Strategies for Brain Tumor Therapy.

ABSTRACT:

Background

A key challenge in the medical treatment of brain tumors is the limited penetration of most chemotherapeutic agents across the blood-brain barrier (BBB) into the tumor and the infiltrative margin around the tumor. Magnetic resonance-guided focused ultrasound (MRgFUS) is a promising tool to enhance the delivery of chemotherapeutic agents into brain tumors.

Objective

To review the mechanism of FUS, preclinical evidence, and clinical studies that used low-frequency FUS for a BBB opening in gliomas.

Methods

Literature review.

Results

The potential of externally delivered low-intensity ultrasound for a temporally and spatially precise and predictable disruption of the BBB has been investigated for over a decade, yielding extensive preclinical literature d

SUBMITTER: Bunevicius A 

PROVIDER: S-EPMC7293897 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature