Associations of serum uric acid with incident dementia and cognitive decline in the ARIC-NCS cohort.

ABSTRACT:

Introduction

Elevated serum uric acid (SUA) is associated with cardiovascular risk factors, which often contribute to dementia and dementia-like morbidity, yet several cross-sectional studies have shown protective associations with cognition, which would be consistent with other work showing benefits of elevated SUA through its antioxidant properties.

Methods

We studied 11,169 participants free of dementia and cardiovascular disease from the Atherosclerosis Risk in Communities (ARIC) cohort. SUA was measured in blood samples collected in 1990-92, baseline for this study (age range 47-70 years). Incident dementia was ascertained based on clinical assessments in 2011-13 and 2016-17, surveillance based on dementia screeners conducted over telephone interviews, hospitalization d

SUBMITTER: Alam AB 

PROVIDER: S-EPMC7293945 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature