The Antibacterial Activity and Mechanism of Action of Luteolin Against Trueperella pyogenes.

ABSTRACT:

Purpose

This research aimed to investigate the antibacterial activity and potential mechanism of luteolin against T. pyogenes.

Materials and methods

The broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of luteolin against various T. pyogenes strains. The potential mechanism of action of luteolin was elucidated through testing and analysing the luteolin-induced alterations of T. pyogenes in several aspects, including cell wall, cell membrane, protein expression, nucleic acid content, topoisomerase activity and energy metabolism.

Results

The MIC values of luteolin against various T. pyogenes isolates and ATCC19411 were 78 µg/mL. The increased cell membrane permeability, destruction of cell wall int

SUBMITTER: Guo Y 

PROVIDER: S-EPMC7293968 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature