The spread of chloramphenicol-resistant Neisseria meningitidis in Southeast Asia.

ABSTRACT:

Objectives

Invasive disease caused by Neisseria meningitidis is a significant health concern globally, but our knowledge of the prevailing serogroups, antimicrobial susceptibility patterns, and genetics of N. meningitidis in Southeast Asia is limited. Chloramphenicol resistance in N. meningitidis has rarely been reported, but was first described in isolates from Vietnam in 1998. We aimed to characterise eight chloramphenicol resistant meningococcal isolates collected between 2007 and 2018 from diagnostic microbiology laboratories in Cambodia, Thailand and the Lao People's Democratic Republic (Laos).

Methods

Whole-genome sequencing was used to generate genome sequences from 18 meningococcal isolates including the eight chloramphenicol resistant isolates. We identified antimic

SUBMITTER: Batty EM 

PROVIDER: S-EPMC7294222 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature