Ontology highlight
ABSTRACT:
SUBMITTER: Jia M
PROVIDER: S-EPMC7294236 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Jia Manxue M Liberatore Rachel A RA Guo Yicheng Y Chan Kun-Wei KW Pan Ruimin R Lu Hong H Waltari Eric E Mittler Eva E Chandran Kartik K Finzi Andrés A Kaufmann Daniel E DE Seaman Michael S MS Ho David D DD Shapiro Lawrence L Sheng Zizhang Z Kong Xiang-Peng XP Bieniasz Paul D PD Wu Xueling X
Cell host & microbe 20200420 6
The HIV-1 envelope (Env) undergoes conformational changes during infection. Broadly neutralizing antibodies (bNAbs) are typically isolated by using soluble Env trimers, which do not capture all Env states. To address these limitations, we devised a vesicular stomatitis virus (VSV)-based probe to display membrane-embedded Env trimers and isolated five bNAbs from two chronically infected donors, M4008 and M1214. Donor B cell receptor (BCR) repertoires identified two bNAb lineages, M4008_N1 and M12 ...[more]