Role of oxygen in fetoplacental endothelial responses: hypoxia, physiological normoxia, or hyperoxia?

ABSTRACT: During pregnancy, placental vascular growth, which is essential for supporting the rapidly growing fetus, is associated with marked elevations in blood flow. These vascular changes take place under chronic physiological low O₂ (less than 2-8% O₂ in human; chronic physiological normoxia, CPN) throughout pregnancy. O₂ level below CPN pertinent to the placenta results in placental hypoxia. Such hypoxia can cause severe endothelial dysfunction, which is associated with adverse pregnancy outcomes (e.g., preeclampsia) and high risk of adult-onset cardiovascular diseases in children born to these pregnancy complications. However, our current knowledge about the mechanisms underlying fetoplacental endothelial function is derived primarily from cell models establish

SUBMITTER: Zhou C 

PROVIDER: S-EPMC7294327 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature