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ABSTRACT: Background
Eight different PCV2 genotypes with varying prevalence and clinical impact have been described so far. PCV2 infection is still widespread among the vaccinated population and several experimental studies have clearly demonstrated that there is no induction of a 100% cross-protective immunity between the PCV2 genotypes. Hence, PCV2a-based vaccines may be ineffective. In this longitudinal study, the PCV2 genotype and haplotype evolution in Austria in the years 2002 to 2017 was investigated by phylogenetic analysis of 462 bp-long sequences of the capsid protein gene (ORF2). The obtained findings may be of practical relevance for the future development of vaccination strategies.Results
One hundred thirty four of a total of 161 formalin-fixed and paraffin wax-embedded
SUBMITTER: Weissenbacher-Lang C
PROVIDER: S-EPMC7294622 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature