Dynamic rewiring of the human interactome by interferon signaling.

ABSTRACT:

Background

The type I interferon (IFN) response is an ancient pathway that protects cells against viral pathogens by inducing the transcription of hundreds of IFN-stimulated genes. Comprehensive catalogs of IFN-stimulated genes have been established across species and cell types by transcriptomic and biochemical approaches, but their antiviral mechanisms remain incompletely characterized. Here, we apply a combination of quantitative proteomic approaches to describe the effects of IFN signaling on the human proteome, and apply protein correlation profiling to map IFN-induced rearrangements in the human protein-protein interaction network.

Results

We identify > 26,000 protein interactions in IFN-stimulated and unstimulated cells, many of which involve proteins associated with

SUBMITTER: Kerr CH 

PROVIDER: S-EPMC7294662 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature