Ontology highlight
ABSTRACT:
SUBMITTER: Klosel I
PROVIDER: S-EPMC7294704 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Klösel Ilona I Schmidt Maximilian F MF Kaindl Jonas J Hübner Harald H Weikert Dorothee D Gmeiner Peter P
ACS medicinal chemistry letters 20200522 6
Proteinase-activated receptor 2 (PAR2) is a class A G protein-coupled receptor whose activation has been associated with inflammatory diseases and cancer, thus representing a valuable therapeutic target. Pathophysiological roles of PAR2 are often characterized using peptidic PAR2 agonists. Peptidic ligands are frequently unstable in vivo and show poor bioavailability, and only a few approaches toward drug-like nonpeptidic PAR2 ligands have been described. The herein-described ligand <b>5a</b> (I ...[more]