Identification of Inhibitors of Thrombospondin 1 Activation of TGF-β.
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ABSTRACT:
SUBMITTER: Suto MJ
PROVIDER: S-EPMC7294719 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Identification of Inhibitors of Thrombospondin 1 Activation of TGF-β.
Suto Mark J MJ Gupta Vandana V Mathew Bini B Zhang Wei W Pallero Manuel A MA Murphy-Ullrich Joanne E JE
ACS medicinal chemistry letters 20200507 6
TGF-β has been a target of interest for the treatment of fibrotic diseases and certain cancers. Approaches to target TGF-β include antagonists of the active ligand or TGF-β receptor kinase activity. These approaches have failed in clinical trials due to a lack of effectiveness and a limited therapeutic window. In this context, newer and more selective approaches to target TGF-β are needed. We previously reported that the matricellular protein, thrombospondin 1, activates the latent TGF-β complex ...[more]
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