Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure.

ABSTRACT: We conducted an epigenome-wide association study meta-analysis on blood pressure (BP) in 4820 individuals of European and African ancestry aged 14 to 69. Genome-wide DNA methylation data from peripheral leukocytes were obtained using the Infinium Human Methylation 450k BeadChip. The epigenome-wide association study meta-analysis identified 39 BP-related CpG sites with P<1×10^-5. In silico replication in the CHARGE consortium of 17 010 individuals validated 16 of these CpG sites. Out of the 16 CpG sites, 13 showed novel association with BP. Conversely, out of the 126 CpG sites identified as being associated (P<1×10^-7) with BP in the CHARGE consortium, 21 were replicated in the current study. Methylation levels of all the 34 CpG sites that were cross-valida

SUBMITTER: Huang Y 

PROVIDER: S-EPMC7295009 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature