Loss of association between HbA1c and vascular disease in older adults with type 1 diabetes.

ABSTRACT:

Aims

Robust evidence supports intensive glucose control in those with recently diagnosed type 1 diabetes to reduce the risk of developing micro- and macrovascular complications. Data to support longitudinal glycaemic targets is lacking. We aimed to explore if longer duration of diabetes and greater age might reduce the impact of glycaemia on the risk of vascular complications.

Research and design methods

Data for adults age 20 years or more, was extracted from a clinical database of people with type 1 diabetes cared for at a London teaching hospital. The presence or absence of micro- and macro-vascular complications was recorded. Multivariable logistic regression analysis was performed using HbA1c as independent variable, diabetes duration and age as continuous variable and

SUBMITTER: Ji H 

PROVIDER: S-EPMC7295188 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature