The association between use of proton-pump inhibitors and excess mortality after kidney transplantation: A cohort study.

ABSTRACT:

Background

Chronic use of proton-pump inhibitors (PPIs) is common in kidney transplant recipients (KTRs). However, concerns are emerging about the potential long-term complications of PPI therapy. We aimed to investigate whether PPI use is associated with excess mortality risk in KTRs.

Methods and findings

We investigated the association of PPI use with mortality risk using multivariable Cox proportional hazard regression analyses in a single-center prospective cohort of 703 stable outpatient KTRs, who visited the outpatient clinic of the University Medical Center Groningen (UMCG) between November 2008 and March 2011 (ClinicalTrials.gov Identifier NCT02811835). Independent replication of the results was performed in a prospective cohort of 656 KTRs from the University Hospit

SUBMITTER: Douwes RM 

PROVIDER: S-EPMC7295199 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature