Associations of Air Pollution and Noise with Local Brain Structure in a Cohort of Older Adults.

ABSTRACT:

Background

Despite the importance of understanding associations of air pollution and noise exposure with loss of neurocognitive performance, studies investigating these exposures and local brain structure are limited.

Objective

We estimated associations of residential air pollution and noise exposures with neurocognitive test performance and the local gyrification index (lGI), a marker for local brain atrophy, among older adults.

Methods

For n=615 participants from the population-based 1000BRAINS study, based on the German Heinz Nixdorf Recall study, we assessed residential exposures to particulate matter (PM10, PM2.5, PM2.5abs), accumulation mode particle number (PNAM), and nitrogen oxides (NOx, NO2), using land-use regression and chemistry transport models. Weighted

SUBMITTER: Nußbaum R 

PROVIDER: S-EPMC7295241 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature