Quantitative iTRAQ LC-MS/MS reveals muscular proteome profiles of deep pressure ulcers.

ABSTRACT: Pressure ulcers (PUs) are a common clinical issue lacking effective treatment and validated pharmacological therapy in hospital settings. Ischemia-reperfusion injury of deep tissue, especially muscle, plays a vital role in the formation and development of the overwhelming majority of PUs. However, muscular protein expression study in PUs has not been reported. Herein, we aimed to investigate the muscular proteins profiles in PUs and to explore the pathological mechanism of PUs. The iTRAQ LC-MS/MS was conducted to detect the protein profiles in clinical muscle samples of PUs. The GO and KEGG pathways analyses were performed for annotation of differentially expressed proteins. Protein-protein interaction (PPI) network was constructed by STRING online database, and hub proteins were validated

SUBMITTER: Liu Z 

PROVIDER: S-EPMC7295623 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature