Weighted gene correlation network analysis reveals novel regulatory modules associated with recurrent early pregnancy loss.

ABSTRACT: At present, the etiology and pathogenesis of recurrent early pregnancy loss (REPL) are not completely clear. Therefore, identifying the underlying diagnostic and prognostic biomarkers of REPL can provide new ideas for the diagnosis and treatment of REPL. The chip data of REPL (GSE63901) were downloaded from the NCBI Gene Expression Omnibus (GEO) database. Weighted Gene Co-Expression Network Analysis (WGCNA) was used to construct a co-expression module for studying the relationship between gene modules and clinical features. In addition, functional analysis of hub genes in modules of interest was performed. A total of 23 co-expression modules were identified, two of which were most significantly associated with three clinical features. The MEbrown module was positively correlated with cycli

SUBMITTER: Li X 

PROVIDER: S-EPMC7295631 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature