Histopathology of brain AVMs part II: inflammation in arteriovenous malformation of the brain.

ABSTRACT:

Background

Hemorrhage from an arteriovenous malformation of the brain (bAVM) has been associated with focal inflammation of the bAVM. Intrigued by the possibility of anti-inflammatory drug therapy to stabilize bAVMs and prevent hemorrhage, we investigated the association of bAVM inflammation with other histological features and clinical presentation.

Materials and methods

Tissue samples from 85 surgically treated bAVMs were studied with histology and CD45 immunostainings. The histological data was compared with the clinical history of the patient. Univariate analysis and logistic regression were performed.

Results

Inflammation was found in all studied bAVMs and did not associate with rupture (p = 0.442). While multiple types of inflammatory cells were present, macroph

SUBMITTER: Wright R 

PROVIDER: S-EPMC7295713 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature