The effect of caffeine on cognitive performance is influenced by CYP1A2 but not ADORA2A genotype, yet neither genotype affects exercise performance in healthy adults.

ABSTRACT:

Purpose

To determine the influence of two commonly occurring genetic polymorphisms on exercise, cognitive performance, and caffeine metabolism, after caffeine ingestion.

Methods

Eighteen adults received caffeine or placebo (3 mg kg^-1) in a randomised crossover study, with measures of endurance exercise (15-min cycling time trial; 70-min post-supplementation) and cognitive performance (psychomotor vigilance test; PVT; pre, 50 and 95-min post-supplementation). Serum caffeine and paraxanthine were measured (pre, 30 and 120-min post-supplementation), and polymorphisms in ADORA2A (rs5751876) and CYP1A2 (rs762551) genes analysed.

Results

Caffeine enhanced exercise performance (P < 0.001), but effects were not different between participants with ADORA2A 'high' (n 

SUBMITTER: Carswell AT 

PROVIDER: S-EPMC7295849 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature