Insights from the in silico structural, functional and phylogenetic characterization of canine lysyl oxidase protein.

ABSTRACT:

Background

Lysyl oxidase is an extracellular regulatory enzyme with an imperative role in interlinking of collagen and elastin by oxidizing lysine residues. Lysyl oxidase has been implicated in incidence of mammary tumors in bitches. Therefore, it becomes significant to study the structural and functional features of this enzyme for a better understanding of its molecular mechanisms.

Results

The detailed computational investigation of the canine lysyl oxidase protein was analyzed in silico with respect to its physicochemical properties, secondary and tertiary structure predictions and functional analysis using standard bioinformatic tools. Lysyl oxidase is a flexible protein with an average molecular weight of around 46 kDa, unstable, hydrophilic, and extracellular (secretor

SUBMITTER: Saleem A 

PROVIDER: S-EPMC7295881 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature