Tumour-to-liver ratio determined by [⁶⁸Ga]Ga-DOTA-TOC PET/CT as a prognostic factor of lanreotide efficacy for patients with well-differentiated gastroenteropancreatic-neuroendocrine tumours.

ABSTRACT:

Background

Lanreotide is a long-acting somatostatin analogue with proven antitumour effects against well-differentiated (WD) gastroenteropancreatic-neuroendocrine tumours (GEP-NETs). However, there are no globally established prognostic factors associated with the efficacy of lanreotide as a treatment for GEP-NETs. We investigated the prognostic value of [⁶⁸Ga]Ga-DOTA-TOC positron emission tomography (PET)/computed tomography (CT) somatostatin receptor imaging for patients with WD GEP-NETs treated with lanreotide.

Methods

In this retrospective study, we included 31 patients with unresectable or metastatic WD GEP-NETs who received lanreotide and underwent [⁶⁸Ga]Ga-DOTA-TOC PET/CT before receiving lanreotide. We captured the following clinicopathological

SUBMITTER: Kim YI 

PROVIDER: S-EPMC7295884 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature