Using Systolic Local Mechanical Load to Predict Fiber Orientation in Ventricles.

ABSTRACT: A simple rule adopted for myofiber reorientation in the ventricles is pursued by taking the microscopic branching network of myocytes into account. The macroscopic active tension generated on the microscopic branching structure is modeled by a multidirectional active stress tensor, which is defined as a function of the strains in the branching directions. In our reorientation algorithm, the principal direction of the branching network is updated so that it turns in the direction of greater active tension in the isovolumetric systole. Updates are performed step-by-step after the mechanical equilibrium has been attained with the current fiber structure. Starting from a nearly flat distribution of the principal fiber orientation along the circumferential direction, the reoriented fiber helix

SUBMITTER: Washio T 

PROVIDER: S-EPMC7295989 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature