Human ZKSCAN3 and Drosophila M1BP are functionally homologous transcription factors in autophagy regulation.

ABSTRACT: Autophagy is an essential cellular process that maintains homeostasis by recycling damaged organelles and nutrients during development and cellular stress. ZKSCAN3 is the sole identified master transcriptional repressor of autophagy in human cell lines. How ZKSCAN3 achieves autophagy repression at the mechanistic or organismal level however still remains to be elucidated. Furthermore, Zkscan3 knockout mice display no discernable autophagy-related phenotypes, suggesting that there may be substantial differences in the regulation of autophagy between normal tissues and tumor cell lines. Here, we demonstrate that vertebrate ZKSCAN3 and Drosophila M1BP are functionally homologous transcription factors in autophagy repression. Expression of ZKSCAN3 in Drosophila prevents premature autophagy ons

SUBMITTER: Barthez M 

PROVIDER: S-EPMC7296029 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature