A Feedforward Loop within the Thyroid-Brown Fat Axis Facilitates Thermoregulation.

ABSTRACT: Thyroid hormones (TH) control brown adipose tissue (BAT) activation and differentiation, but their subsequent homeostatic response following BAT activation remains obscure. This study aimed to investigate the relationship between cold- and capsinoids-induced BAT activation and TH changes between baseline and 2 hours post-intervention. Nineteen healthy subjects underwent ¹⁸F-fluorodeoxyglucose positron-emission tomography (¹⁸F-FDG PET) and whole-body calorimetry (WBC) after 2 hours of cold exposure (~14.5 °C) or capsinoids ingestion (12 mg) in a crossover design. Standardized uptake values (SUV-mean) of the region of interest and energy expenditure (EE) were measured. Plasma free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) were me

SUBMITTER: Sun L 

PROVIDER: S-EPMC7296032 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature