Phenotypic Variation and Carbapenem Resistance Potential in OXA-499-Producing Acinetobacter pittii.

ABSTRACT: Acinetobacter pittii is increasingly recognized as a clinically important species. Here, we identified a carbapenem-non-resistant A. pittii clinical isolate, A1254, harboring bla _{OXA- 499}, bla _{OXA- 826}, and bla _{ADC- 221}. The bla _{OXA- 499} genetic environment in A1254 was identical to that of another OXA-499-producing, but carbapenem-resistant, A. pittii isolate, YMC2010/8/T346, indicating the existence of phenotypic variation among OXA-499-producing A. pittii strains. Under imipenem-selective pressure, the A1254 isolate developed resistance to carbapenems in 60 generations. Two carbapenem-resistant mutants (CAB009 and CAB010) with mutations in the <

SUBMITTER: Zhang L 

PROVIDER: S-EPMC7296048 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature