Gut-resident CX3CR1^hi macrophages induce tertiary lymphoid structures and IgA response in situ.

ABSTRACT: Intestinal mononuclear phagocytes (MPs) are composed of heterogeneous dendritic cell (DC) and macrophage subsets necessary for the initiation of immune response and control of inflammation. Although MPs in the normal intestine have been extensively studied, the heterogeneity and function of inflammatory MPs remain poorly defined. We performed phenotypical, transcriptional, and functional analyses of inflammatory MPs in infectious Salmonella colitis and identified CX3CR1⁺ MPs as the most prevalent inflammatory cell type. CX3CR1⁺ MPs were further divided into three distinct populations, namely, Nos2 ⁺CX3CR1^lo, Ccr7 ⁺CX3CR1^int (lymph migratory), and Cxcl13 ⁺CX3CR1^hi (mucosa resi

SUBMITTER: Koscso B 

PROVIDER: S-EPMC7296464 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature