Molecular Pathogenesis and Interventional Strategies for Alzheimer's Disease: Promises and Pitfalls.

ABSTRACT: Alzheimer's disease (AD) is a debilitating disorder characterized by age-related dementia, which has no effective treatment to date. β-Amyloid depositions and hyperphosphorylated tau proteins are the main pathological hallmarks, along with oxidative stress, N-methyl-d-aspartate (NMDA) receptor-mediated excitotoxicity, and low levels of acetylcholine. Current pharmacotherapy for AD only provides symptomatic relief and limited improvement in cognitive functions. Many molecules have been explored that show promising outcomes in AD therapy and can regulate cellular survival through different pathways. To have a vivid approach to strategize the treatment regimen, AD physiopathology should be better explained considering diverse etiological factors in conjunction with biochemical disturba

SUBMITTER: Bhute S 

PROVIDER: S-EPMC7296537 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature