Cerebrospinal fluid cytokines in metastatic group 3 and 4 medulloblastoma.

ABSTRACT:

Background

Metastatic medulloblastoma (MB) portends a poor prognosis. Amongst the 4 molecular subtypes, Group 3 and Group 4 patients have a higher incidence of metastatic disease, especially involving the neuroaxis. At present, mechanisms underlying MB metastasis remain elusive. Separately, inflammation has been implicated as a key player in tumour development and metastasis. Cytokines and their inflammation-related partners have been demonstrated to act on autocrine and, or paracrine pathways within the tumour microenvironment for various cancers. In this study, the authors explore the involvement of cerebrospinal fluid (CSF) cytokines in Group 3 and 4 MB patients with disseminated disease.

Methods

This is an ethics approved, retrospective study of prospectively collected d

SUBMITTER: Low SYY 

PROVIDER: S-EPMC7296667 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature