Age-structured vectorial capacity reveals timing, not magnitude of within-mosquito dynamics is critical for arbovirus fitness assessment.

ABSTRACT:

Background

Transmission dynamics of arboviruses like Zika virus are often evaluated by vector competence (the proportion of infectious vectors given exposure) and the extrinsic incubation period (EIP, the time it takes for a vector to become infectious), but vector age is another critical driver of transmission dynamics. Vectorial capacity (VC) is a measure of transmission potential of a vector-pathogen system, but how these three components, EIP, vector competence and vector age, affect VC in concert still needs study.

Methods

The interaction of vector competence, EIP, and mosquito age at the time of infection acquisition (Age_acquisition) was experimentally measured in an Aedes aegypti-ZIKV model system, as well as the age-dependence of probability of survival an

SUBMITTER: Mayton EH 

PROVIDER: S-EPMC7296759 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature