Retinol and α-tocopherol in pregnancy: Establishment of reference intervals and associations with CBC.

ABSTRACT: Profound physiological changes during pregnancy may affect the requirement of retinol and tocopherol, which are essential micronutrients for the maintenance of maternal health and foetal development. However, the current reference intervals (RIs) of retinol and tocopherol are based on non-pregnant population. In the present study, a liquid chromatography-tandem mass spectrometry quantitation method for serum retinol and α-tocopherol was established and validated. In addition, we established trimester-specific RIs of retinol and α-tocopherol using the data from paired screening test for 31,301 outpatients who participated in the prenatal vitamins A/E evaluation program at our hospital using the Hoffmann method, which is a simple indirect RI estimation method that does not require the recrui

SUBMITTER: Liu J 

PROVIDER: S-EPMC7296784 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature