Blunted medial prefrontal cortico-limbic reward-related effective connectivity and depression.

ABSTRACT: Major depressive disorder is a leading cause of disability and significant mortality, yet mechanistic understanding remains limited. Over the past decade evidence has accumulated from case-control studies that depressive illness is associated with blunted reward activation in the basal ganglia and other regions such as the medial prefrontal cortex. However it is unclear whether this finding can be replicated in a large number of subjects. The functional anatomy of the medial prefrontal cortex and basal ganglia has been extensively studied and the former has excitatory glutamatergic projections to the latter. Reduced effect of glutamatergic projections from the prefrontal cortex to the nucleus accumbens has been argued to underlie motivational disorders such as depression, and many prominen

SUBMITTER: Rupprechter S 

PROVIDER: S-EPMC7296844 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature