The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications.

ABSTRACT: Amyotrophic lateral sclerosis is the most common degenerative disorder of motor neurons in adults. As there is no cure, thousands of individuals who are alive at present will succumb to the disease. In recent years, numerous causative genes and risk factors for amyotrophic lateral sclerosis have been identified. Several of the recently identified genes encode kinases. In addition, the hypothesis that (de)phosphorylation processes drive the disease process resulting in selective motor neuron degeneration in different disease variants has been postulated. We re-evaluate the evidence for this hypothesis based on recent findings and discuss the multiple roles of kinases in amyotrophic lateral sclerosis pathogenesis. We propose that kinases could represent promising therapeutic targets. Mainly

SUBMITTER: Guo W 

PROVIDER: S-EPMC7296858 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature