Clinical significance and biological mechanisms of glutathione S-transferase mu gene family in colon adenocarcinoma.

ABSTRACT:

Background

Colon adenocarcinoma (COAD) is the most common form of colon cancer. The glutathione S-transferase Mu (GSTM) gene belongs to the GST gene family, which functions in cell metabolism and detoxification. The relationship between GSTM and COAD and the underlying mechanism remain unknown.

Methods

Data extracted from The Cancer Genome Atlas included mRNA expression and clinical information such as gender, age, and tumor stage. Prognostic values of GSTM genes were identified by survival analysis. Function and mechanism of prognostic GSTM genes were identified by gene set enrichment analysis. A nomogram was used to predict the contribution of risk factors to the outcome of COAD patients.

Results

Low expression of GSTM1 and GSTM2 was related to favorable OS (adjuste

SUBMITTER: Guo E 

PROVIDER: S-EPMC7296959 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature