Pediatric HIV: the Potential of Immune Therapeutics to Achieve Viral Remission and Functional Cure.

ABSTRACT:

Purpose of review

In the absence of antiretroviral therapy (ART), more than 50% of perinatally HIV-infected children die by 2 years of age. Early ART from infancy is therefore a global recommendation and significantly improves immune health, child survival, and disease outcome. However, even early treatment does not prevent or eradicate the latent reservoir necessitating life-long ART. Adherence to life-long ART is challenging for children and longstanding ART during chronic HIV infection led to higher risks of non-AIDS co-morbidities and virologic failure in infected children. Thus, HIV-infected children are an important population for consideration for immune-based interventions to achieve ART-free remission and functional cure. This review summarizes how the uniqueness of the ea

SUBMITTER: Berendam SJ 

PROVIDER: S-EPMC7296986 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature